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\u00a1Est\u00e1n abiertas las solicitudes para el Programa de Subvenciones Piloto Cure CLCN4 2023 (plazo hasta el 15 de diciembre de 2023)! La subvenci\u00f3n proporcionar\u00e1 un total de 150.000 \u00a3 para 2-3 proyectos de investigaci\u00f3n centrados en una enfermedad relacionada con CLCN4<\/em>(50.000-75.000 \u00a3\/cada uno). Los detalles de los proyectos subvencionados se anunciar\u00e1n aqu\u00ed a principios de mayo. Para m\u00e1s detalles sobre la subvenci\u00f3n, haz clic aqu\u00ed<\/a>. <\/strong><\/p>\n [\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16″ background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3″ box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bb%912023 – present%93 – Generaci\u00f3n de anticuerpo anti-CIC-4 para su uso en investigaci\u00f3n b\u00e1sica\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1″ header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb18px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb17px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n Justificaci\u00f3n:<\/strong> Los anticuerpos son herramientas esenciales en la investigaci\u00f3n b\u00e1sica, ya que permiten la detecci\u00f3n espec\u00edfica de prote\u00ednas de inter\u00e9s. Esta capacidad de detecci\u00f3n es esencial para comprender los niveles de expresi\u00f3n de las prote\u00ednas, sus modificaciones y su localizaci\u00f3n dentro de las c\u00e9lulas o los tejidos. Mediante el uso de anticuerpos, los investigadores pueden trazar el mapa de d\u00f3nde y cu\u00e1ndo se expresa una prote\u00edna, observar c\u00f3mo cambia su expresi\u00f3n en diferentes condiciones y obtener informaci\u00f3n sobre su papel en diversos procesos celulares. Actualmente no existen anticuerpos validados de forma independiente y ampliamente disponibles para la detecci\u00f3n de CIC-4, la prote\u00edna codificada por el gen CLCN4<\/em>, lo que supone un obst\u00e1culo para la investigaci\u00f3n b\u00e1sica. <\/p>\n Objetivo:<\/strong> El objetivo de este proyecto es desarrollar un conjunto de anticuerpos funcionales para la detecci\u00f3n espec\u00edfica de la prote\u00edna CIC-4. Los proyectos para la generaci\u00f3n de un anticuerpo policlonal y monoclonal est\u00e1n en curso (\u00a1pronto se dar\u00e1n m\u00e1s detalles!). <\/p>\n Resultado (en curso)<\/strong><\/p>\n [\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16″ background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3″ box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bb%912021 – 2023%93 – Proyecto de generaci\u00f3n de modelos Clcn4-rat (50.000 \u00a3)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1″ header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb17px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb17px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n Justificaci\u00f3n:<\/strong> Los esfuerzos de investigaci\u00f3n sobre la afecci\u00f3n del neurodesarrollo relacionada con CLCN4<\/em>(CLCN4-NDC<\/em>) se han visto obstaculizados por la falta de un modelo animal apropiado. Las l\u00edneas de ratones Clcn4<\/em> knockout (KO) generadas anteriormente no mostraban un fenotipo manifiesto (se desarrollaban con normalidad, sin cambios anat\u00f3micos en el cerebro ni anomal\u00edas conductuales evidentes)[1<\/a>,2<\/a>,3<\/a>]. Esto puede deberse a que el gen Clcn4<\/em> del rat\u00f3n es autos\u00f3mico, en lugar de estar ligado al cromosoma X. Con el fin de superar este obst\u00e1culo, y dado que el gen Clcn4<\/em> se encuentra en el cromosoma X en las ratas, lo que significa que el propio gen Clcn4<\/em> de la rata y su entorno en el genoma est\u00e1n mejor conservados, Cure CLCN4 se propuso generar un modelo\/s de rata de CLCN4-NDC<\/em>. <\/p>\n Objetivo:<\/strong> El objetivo de este proyecto era generar tres modelos de rata Clcn4<\/em>: i) una rata Clcn4<\/em> knockout; ii) una rata Clcn4<\/em> knockout condicional, y iii) una l\u00ednea Clcn4<\/em> knock-in (KI), que alberga el equivalente en rata de la variante p.(Ala555Val) CLCN4<\/em>, la variante recurrente m\u00e1s com\u00fan con un fuerte fenotipo de ganancia de funci\u00f3n en el modelo Xenopus<\/em>.<\/p>\n Resultados:<\/strong> Con financiaci\u00f3n proporcionada por Cure CLCN4 y ejecutado por el IGBMC (Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire, Francia), este proyecto ha concluido con \u00e9xito y los tres modelos de rata est\u00e1n disponibles en el repositorio INFRAFRONTIER. 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Estos proyectos son el n\u00facleo de nuestra misi\u00f3n, que consiste en establecer un esfuerzo de colaboraci\u00f3n con investigadores y m\u00e9dicos dedicados, para desentra\u00f1ar la biolog\u00eda de la enfermedad relacionada con el CLCN4 y mejorar la calidad de vida de quienes viven con ella. <\/p>\n","protected":false},"author":2,"featured_media":4781,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7473","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/pages\/7473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/comments?post=7473"}],"version-history":[{"count":2,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/pages\/7473\/revisions"}],"predecessor-version":[{"id":7475,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/pages\/7473\/revisions\/7475"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/media\/4781"}],"wp:attachment":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/media?parent=7473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}P\u00f3ngase en contacto. Participe.<\/h2>\n