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header_2_font=\u00bbFaustina|600|||||||\u00bb header_2_text_color=\u00bb#0e7162&#8243; header_2_font_size=\u00bb42px\u00bb header_2_line_height=\u00bb1.4em\u00bb text_orientation=\u00bbcenter\u00bb max_width=\u00bb850px\u00bb module_alignment=\u00bbcenter\u00bb text_font_size_tablet=\u00bb\u00bb text_font_size_phone=\u00bb17px\u00bb text_font_size_last_edited=\u00bbon|phone\u00bb header_2_font_size_tablet=\u00bb32px\u00bb header_2_font_size_phone=\u00bb22px\u00bb header_2_font_size_last_edited=\u00bbon|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h1 style=\"font-weight: 400; text-align: center;\"><span style=\"font-size: large; color: #008080;\">Desde modelos animales y celulares hasta un registro de pacientes, nuestro objetivo es dotar a los cient\u00edficos de los recursos necesarios para impulsar la investigaci\u00f3n sobre la enfermedad <em>relacionada con CLCN4<\/em>. Aqu\u00ed tienes una lista de las herramientas disponibles y futuras para facilitar la investigaci\u00f3n de vanguardia en este campo. <\/span><\/h1>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Screenshot-2023-10-24-at-09.48.55.png\u00bb title_text=\u00bbinvestigaci\u00f3n_cient\u00edfica\u00bb _builder_version=\u00bb4.23.1&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb73%\u00bb module_alignment=\u00bbcenter\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb40px|80px|27px|80px|false|true\u00bb custom_padding_tablet=\u00bb\u00bb custom_padding_phone=\u00bb|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.22.2&#8243; text_font=\u00bbFaustina||||||||\u00bb text_font_size=\u00bb24px\u00bb text_line_height=\u00bb2em\u00bb link_font=\u00bb|700|||||||\u00bb link_text_color=\u00bb#26c699&#8243; header_font=\u00bb||||||||\u00bb header_font_size=\u00bb31px\u00bb header_2_font=\u00bbFaustina|600|||||||\u00bb header_2_text_color=\u00bb#0e7162&#8243; header_2_font_size=\u00bb34px\u00bb header_2_line_height=\u00bb1.4em\u00bb text_orientation=\u00bbcenter\u00bb max_width=\u00bb850px\u00bb module_alignment=\u00bbcenter\u00bb text_font_size_tablet=\u00bb\u00bb text_font_size_phone=\u00bb17px\u00bb text_font_size_last_edited=\u00bbon|phone\u00bb header_2_font_size_tablet=\u00bb32px\u00bb header_2_font_size_phone=\u00bb22px\u00bb header_2_font_size_last_edited=\u00bbon|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h2 style=\"text-align: left;\">Modelos animales y celulares<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbClcn4 modelos de rata (\u00a1ENCARGA YA!)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb15px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb17px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: justify;\">Se dispone de tres modelos de rata <em>Clcn4<\/em> para su uso en investigaci\u00f3n. Los modelos est\u00e1n disponibles en el repositorio INFRAFRONTERA. Para m\u00e1s detalles, env\u00edanos un correo electr\u00f3nico a <a href=\"mailto:info@cureclcn4.org\">info@cureclcn4.org<\/a>  <\/p>\n<ul>\n<li style=\"text-align: justify;\">Eliminaci\u00f3n de <em>Clcn4<\/em> (EM:15193)<\/li>\n<li style=\"text-align: justify;\">Mutaci\u00f3n puntual A549V <em>de Clcn4<\/em>; equivalente a la A555V humana (EM:15194)<\/li>\n<li style=\"text-align: justify;\"><em>Clcn4<\/em> conditional knockout (pronto disponible en el repositorio)<\/li>\n<\/ul>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Screenshot-2023-10-24-at-09.46.13.png\u00bb title_text=\u00bbCaptura de pantalla 2023-10-24 a las 09.46.13&#8243; _builder_version=\u00bb4.22.2&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb60%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Screenshot-2023-10-24-at-09.44.03.png\u00bb title_text=\u00bbCaptura de pantalla 2023-10-24 a las 09.44.03&#8243; _builder_version=\u00bb4.22.2&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb58%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbiPSCs derivadas de pacientes Clcn4 (Previsto ene-2024)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb15px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb17px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: justify;\">Las siguientes l\u00edneas de c\u00e9lulas madre pluripotentes inducidas (iPSC) derivadas de <em>pacientes Clcn4<\/em> est\u00e1n en proceso de generaci\u00f3n, a trav\u00e9s del programa iPSC de Simons Searchlight. Esperamos disponer de las l\u00edneas celulares a principios de 2024. Para m\u00e1s detalles, env\u00edanos un correo electr\u00f3nico a <a href=\"mailto:info@cureclcn4.org\">info@cureclcn4.org<\/a>  <\/p>\n<ul>\n<li style=\"text-align: justify;\"><i>c.1664C&gt;T (p.Ala555Val)<\/i><\/li>\n<li style=\"text-align: justify;\"><i>c.1465C&gt;A (p.Gln489Lys)<\/i><\/li>\n<li style=\"text-align: justify;\"><i>c.2152C&gt;T (p.Arg718Trp)<\/i><\/li>\n<li style=\"text-align: justify;\"><i>c.1630G&gt;A p (Gly544Arg)<\/i><\/li>\n<\/ul>\n<p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb40px|80px|27px|80px|false|true\u00bb custom_padding_tablet=\u00bb\u00bb custom_padding_phone=\u00bb|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.22.2&#8243; text_font=\u00bbFaustina||||||||\u00bb text_font_size=\u00bb24px\u00bb text_line_height=\u00bb2em\u00bb link_font=\u00bb|700|||||||\u00bb link_text_color=\u00bb#26c699&#8243; header_font=\u00bb||||||||\u00bb header_font_size=\u00bb31px\u00bb header_2_font=\u00bbFaustina|600|||||||\u00bb header_2_text_color=\u00bb#0e7162&#8243; header_2_font_size=\u00bb34px\u00bb header_2_line_height=\u00bb1.4em\u00bb text_orientation=\u00bbcenter\u00bb max_width=\u00bb850px\u00bb module_alignment=\u00bbcenter\u00bb text_font_size_tablet=\u00bb\u00bb text_font_size_phone=\u00bb17px\u00bb text_font_size_last_edited=\u00bbon|phone\u00bb header_2_font_size_tablet=\u00bb32px\u00bb header_2_font_size_phone=\u00bb22px\u00bb header_2_font_size_last_edited=\u00bbon|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h2 style=\"text-align: left;\">Registro de pacientes<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700|||||||\u00bb header_font_size=\u00bb16px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb17px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: justify;\">Cure CLCN4 se enorgullece de asociarse con <strong>Simons<\/strong> Searchlight para albergar un registro formal de pacientes con una afecci\u00f3n del neurodesarrollo <em>relacionada con CLCN4<\/em>. Los investigadores pueden acceder a los datos de Simons Searchlight (incluidos datos gen\u00e9ticos y fenot\u00edpicos y bioespec\u00edmenes) a trav\u00e9s de su portal SFARI Base, que cuenta con el apoyo de la Iniciativa de Investigaci\u00f3n sobre el Autismo de la Fundaci\u00f3n Simons (SFARI). Para consultar la lista de variantes <em>de Clcn4<\/em> incluidas en el registro, haz clic <a href=\"https:\/\/sf-web-assets-prod.s3.amazonaws.com\/wp-content\/uploads\/sites\/2\/2023\/07\/26185939\/Simons-Searchlight-Genetic-Variants-Jan-2023.xlsx\" target=\"_blank\" rel=\"noopener\">aqu\u00ed<\/a>. Para m\u00e1s informaci\u00f3n, puedes visitar el <a href=\"https:\/\/www.simonssearchlight.org\/research\/for-scientists\/\" target=\"_blank\" rel=\"noopener\">sitio web<\/a> de Simons Searchlight o enviarnos un correo electr\u00f3nico a <a href=\"mailto:info@cureclcn4.org\">info@cureclcn4.org.<\/a>   <\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Screenshot-2023-10-24-at-09.43.57.png\u00bb title_text=\u00bbCaptura de pantalla 2023-10-24 a las 09.43.57&#8243; _builder_version=\u00bb4.22.2&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb66%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; admin_label=\u00bbVideo\u00bb _builder_version=\u00bb4.16&#8243; 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Participe.<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb850px\u00bb custom_padding=\u00bb60px|60px|60px|60px|true|true\u00bb animation_style=\u00bbslide\u00bb animation_direction=\u00bbtop\u00bb animation_intensity_slide=\u00bb2%\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb850px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_contact_form email=\u00bbinfo@cureclcn4.org\u00bb success_message=\u00bbGracias por ponerte en contacto con nosotros. Nos pondremos en contacto pronto.\u00bb module_id=\u00bbet_pb_contact_form_1&#8243; _builder_version=\u00bb4.16&#8243; form_field_background_color=\u00bbrgba(0,0,0,0)\u00bb form_field_font=\u00bb||||||||\u00bb custom_button=\u00bbon\u00bb button_text_size=\u00bb14px\u00bb button_text_color=\u00bb#ffffff\u00bb button_bg_color=\u00bb#26c699&#8243; button_border_width=\u00bb8px\u00bb button_border_color=\u00bbrgba(0,0,0,0)\u00bb button_letter_spacing=\u00bb1px\u00bb button_font=\u00bb|700||on|||||\u00bb border_radii=\u00bbon|3px|3px|3px|3px\u00bb border_width_all=\u00bb1px\u00bb border_color_all=\u00bbrgba(51,51,51,0.15)\u00bb form_background_color=\u00bbrgba(0,0,0,0)\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_contact_field field_id=\u00bbName\u00bb field_title=\u00bbNombre\u00bb _builder_version=\u00bb4.16&#8243; global_colors_info=\u00bb{}\u00bb button_text_size__hover_enabled=\u00bboff\u00bb button_one_text_size__hover_enabled=\u00bboff\u00bb button_two_text_size__hover_enabled=\u00bboff\u00bb button_text_color__hover_enabled=\u00bboff\u00bb button_one_text_color__hover_enabled=\u00bboff\u00bb button_two_text_color__hover_enabled=\u00bboff\u00bb button_border_width__hover_enabled=\u00bboff\u00bb button_one_border_width__hover_enabled=\u00bboff\u00bb button_two_border_width__hover_enabled=\u00bboff\u00bb button_border_color__hover_enabled=\u00bboff\u00bb button_one_border_color__hover_enabled=\u00bboff\u00bb button_two_border_color__hover_enabled=\u00bboff\u00bb button_border_radius__hover_enabled=\u00bboff\u00bb button_one_border_radius__hover_enabled=\u00bboff\u00bb button_two_border_radius__hover_enabled=\u00bboff\u00bb button_letter_spacing__hover_enabled=\u00bboff\u00bb button_one_letter_spacing__hover_enabled=\u00bboff\u00bb button_two_letter_spacing__hover_enabled=\u00bboff\u00bb button_bg_color__hover_enabled=\u00bboff\u00bb button_one_bg_color__hover_enabled=\u00bboff\u00bb button_two_bg_color__hover_enabled=\u00bboff\u00bb][\/et_pb_contact_field][et_pb_contact_field field_id=\u00bbEmail\u00bb field_title=\u00bbCorreo electr\u00f3nico\u00bb field_type=\u00bbemail\u00bb _builder_version=\u00bb4.16&#8243; 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