{"id":7564,"date":"2026-01-06T19:25:41","date_gmt":"2026-01-06T19:25:41","guid":{"rendered":"https:\/\/cureclcn4.org\/red-de-investigacion-clcn4\/"},"modified":"2026-01-06T19:25:44","modified_gmt":"2026-01-06T19:25:44","slug":"red-de-investigacion-clcn4","status":"publish","type":"page","link":"https:\/\/cureclcn4.org\/es\/red-de-investigacion-clcn4\/","title":{"rendered":"Red de Investigaci\u00f3n CLCN4"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; admin_label=\u00bbVideo\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#3a897e\u00bb custom_padding=\u00bb0|1px|0|0px|false|false\u00bb collapsed=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.16&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_divider show_divider=\u00bboff\u00bb 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header_2_text_color=\u00bb#0e7162&#8243; header_2_font_size=\u00bb42px\u00bb header_2_line_height=\u00bb1.4em\u00bb text_orientation=\u00bbcenter\u00bb max_width=\u00bb850px\u00bb module_alignment=\u00bbcenter\u00bb text_font_size_tablet=\u00bb\u00bb text_font_size_phone=\u00bb17px\u00bb text_font_size_last_edited=\u00bbon|phone\u00bb header_2_font_size_tablet=\u00bb32px\u00bb header_2_font_size_phone=\u00bb22px\u00bb header_2_font_size_last_edited=\u00bbon|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h1 style=\"font-weight: 400; text-align: center;\"><span style=\"font-size: large; color: #008080;\"><\/span><\/h1>\n<h1 style=\"font-weight: 400; text-align: center;\"><span style=\"font-size: large; color: #008080;\"><\/span><\/h1>\n<h1 style=\"font-weight: 400; text-align: center;\"><span style=\"font-size: large; color: #008080;\">Conoce a la fuerza impulsora de nuestra misi\u00f3n: investigadores y m\u00e9dicos de todo el mundo que trabajan incansablemente para desentra\u00f1ar las complejidades de las enfermedades <em>relacionadas con el CLCN4<\/em>. Bienvenido al coraz\u00f3n de nuestra investigaci\u00f3n. <\/span><\/h1>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_2&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-05-at-13.13.34.png\u00bb title_text=\u00bbCaptura de pantalla 2023-12-05 a las 13.13.34&#8243; _builder_version=\u00bb4.23.1&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb72%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_4,1_4&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb3_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbDra. Vera Kalscheuer (Instituto Max Planck de Gen\u00e9tica Molecular, Alemania)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb15px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb16px\u00bb body_line_height=\u00bb2em\u00bb width=\u00bb100%\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"font-weight: 400; text-align: justify;\"><span>El trabajo de Vera se centra en la identificaci\u00f3n de nuevos genes relacionados con discapacidades del neurodesarrollo, y en la caracterizaci\u00f3n molecular y funcional de genes y prote\u00ednas seleccionados para comprender mejor los mecanismos moleculares y patol\u00f3gicos subyacentes. Con sus investigaciones, ha descubierto y contribuido a la identificaci\u00f3n de numerosos genes vinculados a diversas formas de discapacidades del neurodesarrollo, incluido <em>el CLCN4<\/em>, estableciendo as\u00ed un diagn\u00f3stico molecular para los pacientes y sus familias. Para comprender mejor los trastornos <em>relacionados con el CLCN4<\/em>, junto con la Dra. Emma Palmer y el Dr. Michel Pusch, ha realizado varios estudios sobre el impacto gen\u00e9tico, cl\u00ednico y funcional de las variantes <em>del CLCN4<\/em> recientemente identificadas. Para saber m\u00e1s sobre el trabajo de Vera, haz clic <a href=\"https:\/\/www.molgen.mpg.de\/3415877\/Chromosome-Rearrangements-and-Disease\" target=\"_blank\" rel=\"noopener\">aqu\u00ed<\/a>.   <\/span><\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Vera_headshot-modified.png\u00bb title_text=\u00bbVera_foto-modificada\u00bb _builder_version=\u00bb4.22.2&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_4,1_4&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb3_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbDr. Michael Pusch (Instituto de Biof\u00edsica, Italia)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb15px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb16px\u00bb body_line_height=\u00bb2em\u00bb width=\u00bb100%\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"font-weight: 400; text-align: justify;\">Mi grupo de investigaci\u00f3n tiene una larga experiencia en la caracterizaci\u00f3n biof\u00edsica de canales y transportadores i\u00f3nicos, con \u00e9nfasis en los canales ani\u00f3nicos, utilizando t\u00e9cnicas electrofisiol\u00f3gicas y \u00f3pticas de alta resoluci\u00f3n y expresi\u00f3n en ovocitos de Xenopus y l\u00edneas celulares de mam\u00edferos. El laboratorio tambi\u00e9n realiza rutinariamente mutag\u00e9nesis dirigida al sitio para introducir mutaciones en las construcciones de expresi\u00f3n. Hemos participado en el descubrimiento de nuevos mecanismos moleculares subyacentes a trastornos del neurodesarrollo y neurodegenerativos causados por variantes en los genes que codifican los intercambiadores endolisos\u00f3micos de cloruro\/prot\u00f3n ClC-3, ClC-4 y ClC-6. Seguimos caracterizando funcionalmente las variantes de los genes ClC asociadas a enfermedades, con especial \u00e9nfasis en ClC-4 y su interacci\u00f3n con ClC-3, en una fruct\u00edfera colaboraci\u00f3n con las doctoras Vera Kalscheuer, Emma Palmer y Ra\u00fal Guzm\u00e1n. <span>Para saber m\u00e1s sobre el trabajo de Michael, haz clic <a href=\"http:\/\/users.ge.ibf.cnr.it\/pusch\/\" target=\"_blank\" rel=\"noopener\">aqu\u00ed<\/a>.<\/span>    <\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Michael-modified-modified.png\u00bb title_text=\u00bbMichael-modificado-modificado\u00bb _builder_version=\u00bb4.22.2&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb100%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_4,1_4&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb3_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbDra. Elizabeth Emma Palmer (Red del Hospital Infantil de Sydney y UNSW, AUSTRALIA)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb15px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb16px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"font-weight: 400; text-align: justify;\">Emma es profesora cl\u00ednica s\u00e9nior en la Universidad de Nueva Gales del Sur, Australia, y tiene una beca de investigaci\u00f3n (Investigator Grant) del NHMRC (Consejo Nacional de Salud e Investigaci\u00f3n M\u00e9dica). Su trabajo como genetista cl\u00ednica, atendiendo a familias con enfermedades gen\u00e9ticas raras en el Hospital Infantil de S\u00eddney, sirve de base a su investigaci\u00f3n, cuyo objetivo es mejorar el itinerario del paciente para los 2 millones de australianos y los 300 millones de personas de todo el mundo con una enfermedad rara, de forma equitativa y respetuosa. Emma conoci\u00f3 por primera vez a personas con una enfermedad relacionada con el CLCN4 hace m\u00e1s de 10 a\u00f1os, cuando empez\u00f3 a trabajar como consultora de gen\u00e9tica cl\u00ednica. Ha sido un honor conocer a muchas otras personas con esta enfermedad y a sus familias a trav\u00e9s de su trabajo cl\u00ednico desde entonces, y conectar con m\u00e1s de 100 familias y\/o sus m\u00e9dicos en todo el mundo. La investigaci\u00f3n de Emma se ha centrado en intentar comprender la variedad de formas en que los cambios en <em>CLCN4<\/em> pueden afectar a la salud y el aprendizaje de personas de todas las edades, si eso cambia con el tiempo, y c\u00f3mo ese conocimiento puede traducirse en directrices de gesti\u00f3n y en una mejor atenci\u00f3n, terapias y apoyo centrados en la persona. Su objetivo es ayudar a codise\u00f1ar las herramientas y recursos para un modelo \u00f3ptimo de atenci\u00f3n: para que todas las personas con esta afecci\u00f3n puedan vivir sus vidas m\u00e1s felices y plenas.     <span>  <\/span>Puedes leer m\u00e1s sobre Emma y su investigaci\u00f3n en sus sitios web: <span><a href=\"https:\/\/research.unsw.edu.au\/people\/dr-elizabeth-emma-palmer\" target=\"_blank\" rel=\"noopener\">https:\/\/research.unsw.edu.au\/people\/dr-elizabeth-emma-palmer<\/a><\/span> y <span><a href=\"https:\/\/www.geneequal.com\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.geneequal.com\/<\/a><\/span> incluyendo este v\u00eddeo codise\u00f1ado con personas con discapacidad intelectual para mostrar c\u00f3mo un equipo sanitario puede dar un diagn\u00f3stico gen\u00e9tico (en este caso, una afecci\u00f3n relacionada con CLCN4) a un adulto con una afecci\u00f3n del neurodesarrollo de una forma respetuosa y empoderadora<span> <a href=\"https:\/\/research.unsw.edu.au\/people\/dr-elizabeth-emma-palmer\" target=\"_blank\" rel=\"noopener\">.<\/a><\/span><\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Emma_headshot-modified.png\u00bb title_text=\u00bbEmma_headshot-modificado\u00bb _builder_version=\u00bb4.22.2&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb100%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_4,1_4&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb3_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbDr. Ra\u00fal Guzm\u00e1n (Forschungszentrum J\u00fclich, Alemania)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb15px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb16px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: justify;\"><span>Nuestro objetivo es comprender los mecanismos fisiol\u00f3gicos y fisiopatol\u00f3gicos de ClC-3 y ClC-4 y las neuropatolog\u00edas <em>asociadas a CLCN3\/4<\/em> causadas por sus variantes mutantes. Utilizamos tecnolog\u00eda transg\u00e9nica (modelos de rat\u00f3n modificados gen\u00e9ticamente, shRNA knockdown, transducci\u00f3n lentiviral y AAV9), electrofisiolog\u00eda patch-clamp, reconstrucci\u00f3n morfol\u00f3gica 3D, inmunohistoqu\u00edmica, biolog\u00eda molecular y microscop\u00eda confocal para comprender la funci\u00f3n celular y molecular de ClC-3 y ClC-4 en la salud y la enfermedad neuronales. Examinamos las propiedades el\u00e9ctricas y morfol\u00f3gicas de las neuronas hipocampales y tal\u00e1micas a partir de cortes cerebrales agudos u organot\u00edpicos de ratones <em>Clcn3-\/-<\/em>, <em>Clcn4-\/-<\/em> y <em>Clcn4<\/em> knock-in para identificar el origen y la v\u00eda molecular de la disfunci\u00f3n neuronal. Nuestro objetivo final es identificar posibles estrategias farmacol\u00f3gicas para tratar los trastornos <em>relacionados con<\/em> <em>CLCN3<\/em> y <em>CLCN4<\/em>. Tambi\u00e9n utilizamos la expresi\u00f3n heter\u00f3loga en c\u00e9lulas inmortalizadas combinada con electrofisiolog\u00eda de patch-clamp, microscop\u00eda confocal y bioqu\u00edmica de prote\u00ednas para evaluar las propiedades funcionales de <em>las variantes<\/em> <em>CLCN3-<\/em> y <em>CLCN4<\/em>. Recientemente, nuestro grupo ha aclarado el papel de estos transportadores en el proceso de acumulaci\u00f3n vesicular de monoaminas y en la exocitosis, ha demostrado la implicaci\u00f3n funcional de los intercambiadores Cl-\/H+ en la regulaci\u00f3n de las propiedades electrog\u00e9nicas y de excitabilidad de las neuronas sensoriales, y ha caracterizado funcionalmente varios mutantes <em>CLCN4 <\/em>. En estrecha colaboraci\u00f3n con los doctores Tobias Stauber, Michael Push, Jing Peng y Kenneth Myers, seguimos evaluando las <em>variantes<\/em> <em>CLCN3<\/em> y <em>CLCN4<\/em> asociadas a enfermedades. Para saber m\u00e1s sobre el trabajo de Ra\u00fal, haz clic <a href=\"https:\/\/www.fz-juelich.de\/en\/ibi\/ibi-1\/research\/cellular-neurophysiology-dr-raul-e-guzman-1\" target=\"_blank\" rel=\"noopener\">aqu\u00ed<\/a>.        <\/span><\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/10\/Raul_Guzman-modified-modified.png\u00bb title_text=\u00bbRaul_Guzman-modificado-modificado\u00bb _builder_version=\u00bb4.22.2&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb100%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_4,1_4&#8243; custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb29px|80px|28px|80px|false|false\u00bb custom_padding_tablet=\u00bb|80px||80px|false|true\u00bb custom_padding_phone=\u00bb40px|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb3_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbPROF. ANGELA MORGAn (Instituto Murdoch de Investigaci\u00f3n Infantil, Australia)\u00bb content_max_width=\u00bb800px\u00bb _builder_version=\u00bb4.23.1&#8243; header_font=\u00bb|700||on|||||\u00bb header_font_size=\u00bb15px\u00bb header_line_height=\u00bb2em\u00bb body_font_size=\u00bb16px\u00bb body_line_height=\u00bb2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: justify;\"><span>La profesora Angela Morgan es becaria Elizabeth Blackburn del Consejo Nacional de Salud e Investigaci\u00f3n M\u00e9dica (NHMRC) y dirige el grupo de Habla y Lenguaje del Instituto Murdoch de Investigaci\u00f3n Infantil. Angela es tambi\u00e9n Dame Kate Campbell Professorial Fellow de la Universidad de Melbourne y Directora de la cl\u00ednica de Gen\u00f3mica del Habla del Hospital Infantil Real de Melbourne (Australia). Su carrera se ha centrado en comprender la causalidad, los factores predictivos, el pron\u00f3stico y las terapias de los trastornos graves y persistentes del habla y el lenguaje en los ni\u00f1os. M\u00e1s recientemente, el equipo del Centro de Excelencia en Investigaci\u00f3n (CRE) del NHMRC en Habla y Lenguaje de Angela ha identificado m\u00e1s de 30 genes asociados a la apraxia del habla infantil. El trabajo de su equipo se traduce directamente en directrices internacionales para el tratamiento cl\u00ednico de ni\u00f1os con estas raras afecciones gen\u00e9ticas. El equipo de Angela est\u00e1 encantado de trabajar con la comunidad <em>CLCN4<\/em> para comprender mejor el diagn\u00f3stico, el pron\u00f3stico y el tratamiento del habla y el lenguaje en la afecci\u00f3n <em>relacionada con CLCN4<\/em>. La Sra. Alecka Garrett es una logopeda con experiencia en el equipo CRE y est\u00e1 disfrutando trabajando directamente con las familias con el apoyo cercano de Angela y el equipo. Para saber m\u00e1s sobre el trabajo de Angela, haz clic <a href=\"https:\/\/www.geneticsofspeech.org.au\/about-us\/meet-our-investigators\/professor-angela-morgan\/\" target=\"_blank\" rel=\"noopener\">aqu\u00ed<\/a>. Detalles del estudio sobre el habla y el lenguaje <em>del CL<\/em> CN4 <a href=\"https:\/\/www.geneticsofspeech.org.au\/media\/glzdq5oe\/translationalcentreforspeechdisorders_flyerclcn4_v2.pdf\" target=\"_blank\" rel=\"noopener\">aqu\u00ed<\/a>.        <\/span><\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\u00bb1_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-05-at-13.01.21-2.png\u00bb title_text=\u00bbCaptura de pantalla 2023-12-05 a las 13.01.21&#8243; align=\u00bbcenter\u00bb _builder_version=\u00bb4.23.1&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb100%\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=\u00bbon|phone\u00bb _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb1200px\u00bb custom_padding=\u00bb40px|80px|27px|80px|false|true\u00bb custom_padding_tablet=\u00bb\u00bb custom_padding_phone=\u00bb|30px||30px||true\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb1200px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_heading title=\u00bb\u00bfTrabajas en una condici\u00f3n relacionada con el CLCN4 y quieres unirte a nuestra red? \u00a1Ponte en contacto!   \u00bb _builder_version=\u00bb4.23.1&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bbFaustina|600|||||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#0f7162&#8243; title_font_size=\u00bb29px\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_heading][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; admin_label=\u00bbVideo\u00bb _builder_version=\u00bb4.16&#8243; 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Participe.<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.16&#8243; background_color=\u00bb#ffffff\u00bb max_width=\u00bb850px\u00bb custom_padding=\u00bb60px|60px|60px|60px|true|true\u00bb animation_style=\u00bbslide\u00bb animation_direction=\u00bbtop\u00bb animation_intensity_slide=\u00bb2%\u00bb box_shadow_style=\u00bbpreset3&#8243; box_shadow_vertical=\u00bb40px\u00bb box_shadow_blur=\u00bb100px\u00bb box_shadow_spread=\u00bb-30px\u00bb box_shadow_color=\u00bbrgba(0,0,0,0.22)\u00bb use_custom_width=\u00bbon\u00bb custom_width_px=\u00bb850px\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.16&#8243; custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_contact_form email=\u00bbinfo@cureclcn4.org\u00bb success_message=\u00bbGracias por ponerte en contacto con nosotros. 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