{"id":4109,"date":"2023-03-15T08:06:22","date_gmt":"2023-03-15T08:06:22","guid":{"rendered":"https:\/\/cureclcn4.org\/modelos-animales-para-la-enfermedad-relacionada-con-clcn4\/"},"modified":"2023-03-15T08:06:25","modified_gmt":"2023-03-15T08:06:25","slug":"modelos-animales-para-la-enfermedad-relacionada-con-clcn4","status":"publish","type":"post","link":"https:\/\/cureclcn4.org\/es\/modelos-animales-para-la-enfermedad-relacionada-con-clcn4\/","title":{"rendered":"Modelos animales para la enfermedad relacionada con CLCN4"},"content":{"rendered":"

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<\/h1>\n

Clcn4<\/em> modelos de ratas – \u00a1ya est\u00e1n aqu\u00ed! <\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=\u00bb4.20.2″ text_font=\u00bb||||||||\u00bb text_font_size=\u00bb15px\u00bb text_line_height=\u00bb1.8em\u00bb header_font=\u00bbFaustina||||||||\u00bb header_text_color=\u00bb#0e7162″ header_font_size=\u00bb60px\u00bb header_line_height=\u00bb1.3em\u00bb text_orientation=\u00bbjustified\u00bb width=\u00bb100%\u00bb min_height=\u00bb87.2px\u00bb custom_margin=\u00bb-30px||-20px|0px|false|false\u00bb custom_padding=\u00bb20px|8px||0px||\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Gracias a los esfuerzos de recaudaci\u00f3n de fondos de la comunidad CLCN4, que nos ayud\u00f3 a reunir 50.000 libras para este proyecto, y al fant\u00e1stico trabajo del equipo PHENOMIN-ICS (Francia), \u00a1ya<\/a><\/strong> <\/a> hay dos modelos de rata Clcn4<\/em> a disposici\u00f3n de<\/strong> los investigadores!<\/span><\/strong><\/strong> <\/span>\u00bfSe pregunta qu\u00e9 significa esto? Siga leyendo para obtener un resumen f\u00e1cil de entender.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb background_color=\u00bb#FFFFFF\u00bb width=\u00bb100%\u00bb min_height=\u00bb100px\u00bb custom_padding=\u00bb0px||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb67px\u00bb custom_margin=\u00bb||0px||false|false\u00bb custom_padding=\u00bb|10px|0px|10px|false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

\u00bfQu\u00e9 es un modelo animal? <\/strong><\/span><\/h3>\n

Para comprender mejor las complejidades de las afecciones relacionadas con el CLCN4<\/em>, los investigadores necesitan herramientas<\/strong> para estudiarlas.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb background_color=\u00bb#FFFFFF\u00bb width=\u00bb100%\u00bb min_height=\u00bb100px\u00bb custom_margin=\u00bb-24px|auto||auto||\u00bb custom_padding=\u00bb0px||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb width=\u00bb100%\u00bb min_height=\u00bb75.8px\u00bb custom_margin=\u00bb||0px||false|false\u00bb custom_padding=\u00bb|10px|0px|10px|false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Una de estas herramientas es un modelo animal<\/strong>. Un modelo animal es un tipo de animal, como una rata o un rat\u00f3n, que los cient\u00edficos utilizan para estudiar enfermedades y probar posibles tratamientos. Estos animales se modifican gen\u00e9ticamente y se cr\u00edan para imitar aspectos de una enfermedad concreta, como la relacionada con CLCN4<\/em>, de modo que los investigadores puedan comprender mejor c\u00f3mo funciona la enfermedad, c\u00f3mo progresa y c\u00f3mo podr\u00eda tratarse.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb background_color=\u00bb#FFFFFF\u00bb width=\u00bb100%\u00bb min_height=\u00bb221px\u00bb custom_padding=\u00bb0px||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb115.8px\u00bb custom_margin=\u00bb||0px||false|false\u00bb custom_padding=\u00bb|10px|0px|10px|false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

\u00bfPor qu\u00e9 son importantes los modelos animales?<\/strong> <\/strong><\/span><\/h3>\n

Los modelos animales son incre\u00edblemente importantes porque permiten a los cient\u00edficos estudiar enfermedades y probar posibles tratamientos en un entorno controlado antes de probarlos en seres humanos. Esto puede ahorrar tiempo y recursos, y tambi\u00e9n ayuda a garantizar que los tratamientos sean seguros y eficaces antes de administrarlos a las personas. Para la afecci\u00f3n relacionada con CLCN4<\/em>, un modelo animal ayudar\u00e1 a los cient\u00edficos a aprender: <\/span><\/span><\/p>\n

    \n
  • C\u00f3mo act\u00faa en el cerebro la prote\u00edna CIC-4, producida por el gen CLCN4<\/em>.<\/span><\/li>\n
  • C\u00f3mo una mutaci\u00f3n o \u00abfallo\u00bb en el gen CLCN4<\/em> causa los problemas que vemos.<\/span><\/li>\n
  • C\u00f3mo podr\u00edamos tratar la afecci\u00f3n relacionada con CLCN4<\/em> para mejorar la calidad de vida, la salud y las perspectivas.<\/span><\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2″ _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb background_color=\u00bb#FFFFFF\u00bb width=\u00bb100%\u00bb min_height=\u00bb444.5px\u00bb custom_padding=\u00bb0px||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb97.8px\u00bb custom_margin=\u00bb||0px||false|false\u00bb custom_padding=\u00bb|10px|0px|10px|false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

    \u00bfQu\u00e9 modelos de rata Clcn4<\/em> ha generado Cure CLCN4? <\/strong><\/strong><\/span><\/h3>\n

    En t\u00e9rminos simplificados, en los pacientes, los cambios o \u00abfallos\u00bb en el gen CLCN4<\/em> pueden tener uno de dos efectos:<\/span><\/p>\n

    P\u00e9rdida de funci\u00f3n<\/strong>, es decir, la prote\u00edna deja de funcionar.<\/span>
    Una ganancia de funci\u00f3n<\/strong>, lo que significa que la prote\u00edna es m\u00e1s activa o funciona de forma anormal.<\/span><\/p>\n

    Por lo tanto, generamos dos tipos de ratas Clcn4<\/em>:<\/span><\/p>\n

    Una rata a la que le falta el gen Clcn4<\/em>, tambi\u00e9n llamado knockout, y que por tanto imita una p\u00e9rdida de funci\u00f3n.<\/strong><\/span>
    Una rata con un cambio en Clcn4 que en humanos se ha descrito como ganancia de funci\u00f3n<\/strong>, por lo tanto imitando una ganancia de funci\u00f3n<\/strong>.<\/span><\/p>\n

    As\u00ed, las dos ratas generadas coinciden con los dos amplios efectos de los cambios del gen CLCN4<\/em> observados en humanos.<\/span><\/p>\n

    \n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/rat_model_types.png\u00bb title_text=\u00bbtipos_modelo_rata\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb max_width=\u00bb77%\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2″ _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb background_color=\u00bb#FFFFFF\u00bb width=\u00bb100%\u00bb min_height=\u00bb118.5px\u00bb custom_margin=\u00bb|auto|14px|auto||\u00bb custom_padding=\u00bb0px||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb50.8px\u00bb custom_margin=\u00bb||0px||false|false\u00bb custom_padding=\u00bb0px|10px|0px|10px|false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

    \u00bfCu\u00e1l es el siguiente paso?<\/strong><\/strong><\/span><\/h3>\n

    Ahora que las ratas Clcn4<\/em> est\u00e1n aqu\u00ed, el siguiente paso es caracterizarlas, lo que implica estudiarlas en detalle<\/strong> para comprender mejor c\u00f3mo su gen\u00e9tica y biolog\u00eda se relacionan con la enfermedad humana. Esto puede resultar dif\u00edcil y caro, pero es esencial para garantizar que los modelos representen fielmente la enfermedad y puedan utilizarse con eficacia en la investigaci\u00f3n.<\/span><\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/Detailed_look.png\u00bb title_text=\u00bbVista_detallada\u00bb _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb max_width=\u00bb38%\u00bb module_alignment=\u00bbcenter\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2″ _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb background_color=\u00bb#FFFFFF\u00bb width=\u00bb100%\u00bb min_height=\u00bb191px\u00bb custom_padding=\u00bb0px||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb139.8px\u00bb custom_margin=\u00bb||0px||false|false\u00bb custom_padding=\u00bb|10px|0px|10px|false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

    \u00bfPuedo ayudarle? <\/strong><\/strong><\/span><\/h3>\n

    S\u00ed que puedes. El trabajo necesario para caracterizar los modelos de rata es costoso. Si desea ayudarnos a financiar este proyecto, puede
    \n donar<\/u>
    \n<\/strong> o
    \n recaudar fondos<\/u>
    \n<\/strong>. El 100% de las donaciones se destina a investigaci\u00f3n. <\/span><\/p>\n

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    Financiado por<\/strong><\/h1>\n

    [\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/CLCN4_logo_medium-removebg-preview.png\u00bb title_text=\u00bbCLCN4_logo_medium-removebg-preview\u00bb _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb1_3″ _builder_version=\u00bb4.16″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb header_font=\u00bb|||on|||||\u00bb custom_margin=\u00bb||-4px|||\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

    Producido por<\/strong><\/h1>\n

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    Disponible en<\/strong><\/h1>\n

    [\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/Infrafrontier-logo.png\u00bb title_text=\u00bbLogotipo de Infrafrontier\u00bb url=\u00bbhttps:\/\/www.infrafrontier.eu\/emma\/strain-search\/?category=all&keyword=clcn4″ _builder_version=\u00bb4.20.2″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb124.3px\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1″ admin_label=\u00bbSponsors\u00bb _builder_version=\u00bb4.16″ background_color=\u00bbrgba(14,113,98,0.9)\u00bb use_background_color_gradient=\u00bbon\u00bb background_color_gradient_stops=\u00bbrgba(14,113,98,0.9) 0%|#0e7162 100%\u00bb background_color_gradient_overlays_image=\u00bbon\u00bb background_color_gradient_start=\u00bbrgba(14,113,98,0.9)\u00bb background_color_gradient_end=\u00bb#0e7162″ background_image=\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2020\/08\/charity-18.jpg\u00bb custom_padding=\u00bb6vw||6vw||true|false\u00bb box_shadow_style=\u00bbpreset7″ box_shadow_horizontal=\u00bb0px\u00bb box_shadow_vertical=\u00bb-20px\u00bb box_shadow_color=\u00bbrgba(255,255,255,0.12)\u00bb collapsed=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row column_structure=\u00bb2_3,1_3″ _builder_version=\u00bb4.16″ global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb2_3″ _builder_version=\u00bb4.16″ custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_text _builder_version=\u00bb4.16″ text_font=\u00bb||||||||\u00bb text_line_height=\u00bb2em\u00bb ul_font=\u00bb||||||||\u00bb ol_font=\u00bb||||||||\u00bb header_font=\u00bb||||||||\u00bb header_2_font=\u00bbFaustina|600|||||||\u00bb header_2_font_size=\u00bb42px\u00bb header_2_line_height=\u00bb1.4em\u00bb header_3_font=\u00bb||||||||\u00bb header_4_font=\u00bb||||||||\u00bb header_5_font=\u00bb||||||||\u00bb header_6_font=\u00bb||||||||\u00bb background_layout=\u00bbdark\u00bb max_width=\u00bb600px\u00bb header_2_font_size_tablet=\u00bb32px\u00bb header_2_font_size_phone=\u00bb22px\u00bb header_2_font_size_last_edited=\u00bbon|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

    Empresas patrocinadoras de la Fundaci\u00f3n<\/h2>\n

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    P\u00f3ngase en contacto. Participe.<\/h2>\n

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    Gracias a los esfuerzos de recaudaci\u00f3n de fondos de la comunidad CLCN4, que nos ayud\u00f3 a reunir 50.000 libras para este proyecto, y al fant\u00e1stico trabajo del equipo PHENOMIN-ICS (Francia), \u00a1ya hay dos modelos de rata Clcn4 a disposici\u00f3n de los investigadores! \u00bfSe pregunta qu\u00e9 significa esto? Siga leyendo para obtener un resumen f\u00e1cil de entender.<\/p>\n","protected":false},"author":2,"featured_media":4017,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[48],"tags":[],"class_list":["post-4109","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-investigacion"],"_links":{"self":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/posts\/4109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/comments?post=4109"}],"version-history":[{"count":5,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/posts\/4109\/revisions"}],"predecessor-version":[{"id":4114,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/posts\/4109\/revisions\/4114"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/media\/4017"}],"wp:attachment":[{"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/media?parent=4109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/categories?post=4109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cureclcn4.org\/es\/wp-json\/wp\/v2\/tags?post=4109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}