{"id":4103,"date":"2023-03-15T08:04:34","date_gmt":"2023-03-15T08:04:34","guid":{"rendered":"https:\/\/cureclcn4.org\/modeles-animaux-pour-les-affections-liees-a-la-clcn4\/"},"modified":"2023-03-15T08:04:37","modified_gmt":"2023-03-15T08:04:37","slug":"modeles-animaux-pour-les-affections-liees-a-la-clcn4","status":"publish","type":"post","link":"https:\/\/cureclcn4.org\/fr\/modeles-animaux-pour-les-affections-liees-a-la-clcn4\/","title":{"rendered":"Mod\u00e8les animaux pour les affections li\u00e9es \u00e0 la CLCN4"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00a0\u00bb1&Prime; admin_label=\u00a0\u00bbGet Involved\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb background_image=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2020\/08\/charity-13.png\u00a0\u00bb parallax=\u00a0\u00bbon\u00a0\u00bb custom_padding=\u00a0\u00bb0|1px|3px|0px|false|false\u00a0\u00bb use_custom_width=\u00a0\u00bbon\u00a0\u00bb 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align=\u00a0\u00bbcenter\u00a0\u00bb _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb100%\u00a0\u00bb custom_margin=\u00a0\u00bb|||-5px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00a0\u00bb4.20.0&Prime; text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb10px\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb header_font=\u00a0\u00bbFaustina|600|||||||\u00a0\u00bb header_text_color=\u00a0\u00bb#0e7162&Prime; header_font_size=\u00a0\u00bb60px\u00a0\u00bb header_line_height=\u00a0\u00bb1.3em\u00a0\u00bb width=\u00a0\u00bb98.8%\u00a0\u00bb min_height=\u00a0\u00bb89px\u00a0\u00bb custom_margin=\u00a0\u00bb-36px|||0px|false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb50px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb40px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h1 style=\"text-align: center;\"><\/h1>\n<h1 style=\"text-align: center;\">Mod\u00e8les de rats <em>Clcn4<\/em> &#8211; ils sont l\u00e0 !  <\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb15px\u00a0\u00bb text_line_height=\u00a0\u00bb1.8em\u00a0\u00bb header_font=\u00a0\u00bbFaustina||||||||\u00a0\u00bb header_text_color=\u00a0\u00bb#0e7162&Prime; header_font_size=\u00a0\u00bb60px\u00a0\u00bb header_line_height=\u00a0\u00bb1.3em\u00a0\u00bb text_orientation=\u00a0\u00bbjustified\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb87.2px\u00a0\u00bb custom_margin=\u00a0\u00bb-30px||-20px|0px|false|false\u00a0\u00bb custom_padding=\u00a0\u00bb20px|8px||0px||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Gr\u00e2ce aux efforts de la communaut\u00e9 CLCN4, qui nous a permis de r\u00e9colter 50 000 \u00a3 pour ce projet, et au travail fantastique de l&rsquo;\u00e9quipe PHENOMIN-ICS (France), <strong>deux mod\u00e8les de rats <em>Clcn4<\/em> sont <a href=\"https:\/\/www.infrafrontier.eu\/emma\/strain-search\/?category=all&amp;keyword=clcn4%20\" target=\"_blank\" rel=\"noopener\">d\u00e9sormais \u00e0 la disposition<\/a> des <span style=\"color: #000000;\">chercheurs !<\/span><\/strong> <\/span><span style=\"color: #000000;\">Vous vous demandez ce que cela signifie ? Poursuivez votre lecture pour un r\u00e9sum\u00e9 facile \u00e0 comprendre !<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb100px\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb min_height=\u00a0\u00bb67px\u00a0\u00bb custom_margin=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|10px|0px|10px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h3><span style=\"color: #000000;\"><strong>Qu&rsquo;est-ce qu&rsquo;un mod\u00e8le animal ?  <\/strong><\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Pour mieux comprendre la complexit\u00e9 des troubles <em>li\u00e9s \u00e0 la CLCN4<\/em>, les <strong>chercheurs ont besoin d&rsquo;outils<\/strong> pour les \u00e9tudier.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb100px\u00a0\u00bb custom_margin=\u00a0\u00bb-24px|auto||auto||\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb75.8px\u00a0\u00bb custom_margin=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|10px|0px|10px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<p style=\"text-align: justify;\"><strong style=\"color: #000000; font-size: 14px;\">L&rsquo;un de ces outils est un mod\u00e8le animal<\/strong><span style=\"color: #000000; font-size: 14px;\">. Un mod\u00e8le animal est un type d&rsquo;animal, comme le rat ou la souris, que les scientifiques utilisent pour \u00e9tudier les maladies et tester des traitements potentiels. Ces animaux sont g\u00e9n\u00e9tiquement modifi\u00e9s et \u00e9lev\u00e9s pour imiter les aspects d&rsquo;une maladie sp\u00e9cifique, telle que la maladie <em>li\u00e9e au CLCN4,<\/em> afin que les chercheurs puissent mieux comprendre le fonctionnement de la maladie, son \u00e9volution et son traitement.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb221px\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb min_height=\u00a0\u00bb115.8px\u00a0\u00bb custom_margin=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|10px|0px|10px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h3><span style=\"color: #000000;\"><strong>Pourquoi les mod\u00e8les animaux sont-ils importants ?<\/strong> <strong><\/strong><\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Les mod\u00e8les animaux sont extr\u00eamement importants car ils permettent aux scientifiques d&rsquo;\u00e9tudier les maladies et de tester des traitements potentiels dans un environnement contr\u00f4l\u00e9 avant de les essayer chez l&rsquo;homme. Cela permet d&rsquo;\u00e9conomiser du temps et des ressources, et de s&rsquo;assurer que les traitements sont s\u00fbrs et efficaces avant d&rsquo;\u00eatre administr\u00e9s. Pour les troubles <em>li\u00e9s \u00e0 la CLCN4,<\/em> un mod\u00e8le animal aidera les scientifiques \u00e0 en savoir plus :  <\/span><span style=\"color: #000000;\"><\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Comment la prot\u00e9ine CIC-4, fabriqu\u00e9e par le g\u00e8ne <em>CLCN4<\/em>, fonctionne dans le cerveau.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Comment une mutation ou un \u00ab\u00a0d\u00e9faut\u00a0\u00bb dans le g\u00e8ne <em>CLCN4<\/em> provoque les probl\u00e8mes que nous observons.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Comment nous pourrions \u00eatre en mesure de traiter les troubles <em>li\u00e9s \u00e0 la CLCN4<\/em> afin d&rsquo;am\u00e9liorer la qualit\u00e9 de vie, la sant\u00e9 et les perspectives d&rsquo;avenir.<\/span><\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb1_2,1_2&Prime; _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb444.5px\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb min_height=\u00a0\u00bb97.8px\u00a0\u00bb custom_margin=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|10px|0px|10px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h3 style=\"text-align: justify;\"><span style=\"color: #000000;\"><strong>Quels sont les mod\u00e8les de rats <em>Clcn4<\/em> g\u00e9n\u00e9r\u00e9s par Cure CLCN4 ?  <\/strong><strong><\/strong><\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">En termes simplifi\u00e9s, chez les patients, les changements ou \u00ab\u00a0p\u00e9pins\u00a0\u00bb dans le g\u00e8ne <em>CLCN4<\/em> peuvent avoir l&rsquo;un des deux effets suivants :<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\"><strong>Une perte de fonction<\/strong>, c&rsquo;est-\u00e0-dire que la prot\u00e9ine cesse de fonctionner.<\/span><br \/><span style=\"color: #000000;\"><strong>Un gain de fonction<\/strong> &#8211; ce qui signifie que la prot\u00e9ine est plus active ou qu&rsquo;elle fonctionne de mani\u00e8re anormale.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Nous avons donc g\u00e9n\u00e9r\u00e9 deux types de rats <em>Clcn4<\/em>:<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Un rat dont le g\u00e8ne <em>Clcn4<\/em> est absent, \u00e9galement appel\u00e9 knock-out, et qui <strong>reproduit<\/strong> donc <strong>une perte de fonction<\/strong>.<\/span><br \/><span style=\"color: #000000;\">Un rat pr\u00e9sentant une modification de Clcn4 qui, chez l&rsquo;homme, a \u00e9t\u00e9 d\u00e9crite comme un gain de fonction, <strong>imitant ainsi un gain de fonction<\/strong>.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Ainsi, les deux rats g\u00e9n\u00e9r\u00e9s correspondent aux deux grands effets des modifications du g\u00e8ne <em>CLCN4<\/em> observ\u00e9s chez l&rsquo;homme.<\/span><\/p>\n<p style=\"text-align: justify;\">\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/rat_model_types.png\u00a0\u00bb title_text=\u00a0\u00bbrat_model_types\u00a0\u00bb align=\u00a0\u00bbcenter\u00a0\u00bb _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb77%\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb1_2,1_2&Prime; _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb118.5px\u00a0\u00bb custom_margin=\u00a0\u00bb|auto|14px|auto||\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb min_height=\u00a0\u00bb50.8px\u00a0\u00bb custom_margin=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px|10px|0px|10px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h3 style=\"text-align: justify;\"><span style=\"color: #000000;\"><strong>Quelle est la prochaine \u00e9tape ?<\/strong><strong><\/strong><\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Maintenant que les rats <em>Clcn4<\/em> sont l\u00e0, la prochaine \u00e9tape consiste \u00e0 les caract\u00e9riser, c&rsquo;est-\u00e0-dire \u00e0 <strong>les \u00e9tudier en d\u00e9tail<\/strong> pour mieux comprendre comment leur g\u00e9n\u00e9tique et leur biologie sont li\u00e9es \u00e0 la maladie humaine. Cela peut s&rsquo;av\u00e9rer difficile et co\u00fbteux, mais il est essentiel de veiller \u00e0 ce que les mod\u00e8les repr\u00e9sentent fid\u00e8lement la maladie et puissent \u00eatre utilis\u00e9s efficacement dans la recherche.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/Detailed_look.png\u00a0\u00bb title_text=\u00a0\u00bbAper\u00e7u d\u00e9taill\u00e9\u00a0\u00bb _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb38%\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb1_2,1_2&Prime; _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb191px\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb min_height=\u00a0\u00bb139.8px\u00a0\u00bb custom_margin=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|10px|0px|10px|false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h3 style=\"text-align: justify;\"><span style=\"color: #000000;\"><strong>Puis-je vous aider ?  <\/strong><strong><\/strong><\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Si, vous le pouvez ! Le travail n\u00e9cessaire pour caract\u00e9riser les mod\u00e8les de rats est co\u00fbteux. Si vous souhaitez nous aider \u00e0 financer ce projet, vous pouvez <strong><br \/>\n  <u>faire un don<\/u><br \/>\n<\/strong> ou <strong><br \/>\n  <u>collecter des fonds<\/u><br \/>\n<\/strong>. 100% des dons sont destin\u00e9s \u00e0 la recherche.  <\/span><\/p>\n<p style=\"text-align: justify;\">[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/Fundraise.png\u00a0\u00bb title_text=\u00a0\u00bbCollecte de fonds\u00a0\u00bb _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb29%\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb min_height=\u00a0\u00bb111.9px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb1_3,1_3,1_3&Prime; _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb min_height=\u00a0\u00bb162.6px\u00a0\u00bb custom_padding=\u00a0\u00bb71px||1px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_font=\u00a0\u00bb|||on|||||\u00a0\u00bb custom_margin=\u00a0\u00bb||-4px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h1 style=\"text-align: center;\"><strong>Financ\u00e9 par<\/strong><\/h1>\n<p>[\/et_pb_text][et_pb_image src=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/CLCN4_logo_medium-removebg-preview.png\u00a0\u00bb title_text=\u00a0\u00bbCLCN4_logo_medium-removebg-preview\u00a0\u00bb _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_font=\u00a0\u00bb|||on|||||\u00a0\u00bb custom_margin=\u00a0\u00bb||-4px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h1 style=\"text-align: center;\"><strong>Produit par<\/strong><\/h1>\n<p>[\/et_pb_text][et_pb_image src=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/Phenomin.png\u00a0\u00bb title_text=\u00a0\u00bbPh\u00e9nomin\u00a0\u00bb url=\u00a0\u00bbhttp:\/\/www.phenomin.fr\/en-us\/\u00a0\u00bb _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_font=\u00a0\u00bb|||on|||||\u00a0\u00bb min_height=\u00a0\u00bb37px\u00a0\u00bb custom_margin=\u00a0\u00bb||-2px|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h1 style=\"text-align: center;\"><strong>Disponible \u00e0 l&rsquo;adresse suivante<\/strong><\/h1>\n<p>[\/et_pb_text][et_pb_image src=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2023\/03\/Infrafrontier-logo.png\u00a0\u00bb title_text=\u00a0\u00bbLogo d&rsquo;Infrafronti\u00e8re\u00a0\u00bb url=\u00a0\u00bbhttps:\/\/www.infrafrontier.eu\/emma\/strain-search\/?category=all&amp;keyword=clcn4&Prime; _builder_version=\u00a0\u00bb4.20.2&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb min_height=\u00a0\u00bb124.3px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; admin_label=\u00a0\u00bbSponsors\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; background_color=\u00a0\u00bbrgba(14,113,98,0.9)\u00a0\u00bb use_background_color_gradient=\u00a0\u00bbon\u00a0\u00bb background_color_gradient_stops=\u00a0\u00bbrgba(14,113,98,0.9) 0%|#0e7162 100%\u00a0\u00bb background_color_gradient_overlays_image=\u00a0\u00bbon\u00a0\u00bb background_color_gradient_start=\u00a0\u00bbrgba(14,113,98,0.9)\u00a0\u00bb background_color_gradient_end=\u00a0\u00bb#0e7162&Prime; background_image=\u00a0\u00bbhttps:\/\/cureclcn4.org\/wp-content\/uploads\/2020\/08\/charity-18.jpg\u00a0\u00bb custom_padding=\u00a0\u00bb6vw||6vw||true|false\u00a0\u00bb box_shadow_style=\u00a0\u00bbpreset7&Prime; box_shadow_horizontal=\u00a0\u00bb0px\u00a0\u00bb box_shadow_vertical=\u00a0\u00bb-20px\u00a0\u00bb box_shadow_color=\u00a0\u00bbrgba(255,255,255,0.12)\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_row column_structure=\u00a0\u00bb2_3,1_3&Prime; _builder_version=\u00a0\u00bb4.16&Prime; global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_3&Prime; _builder_version=\u00a0\u00bb4.16&Prime; custom_padding=\u00a0\u00bb|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.16&Prime; text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb ul_font=\u00a0\u00bb||||||||\u00a0\u00bb ol_font=\u00a0\u00bb||||||||\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbFaustina|600|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb42px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_3_font=\u00a0\u00bb||||||||\u00a0\u00bb header_4_font=\u00a0\u00bb||||||||\u00a0\u00bb header_5_font=\u00a0\u00bb||||||||\u00a0\u00bb header_6_font=\u00a0\u00bb||||||||\u00a0\u00bb background_layout=\u00a0\u00bbdark\u00a0\u00bb max_width=\u00a0\u00bb600px\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb32px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb22px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h2>Sponsors de la Fondation d&rsquo;entreprise<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3&Prime; _builder_version=\u00a0\u00bb4.16&Prime; custom_padding=\u00a0\u00bb|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_button button_url=\u00a0\u00bbhttps:\/\/cureclcn4.org\/fr\/contact\/\u00a0\u00bb button_text=\u00a0\u00bbDevenir un sponsor\u00a0\u00bb button_alignment=\u00a0\u00bbright\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; custom_button=\u00a0\u00bbon\u00a0\u00bb button_text_size=\u00a0\u00bb14px\u00a0\u00bb button_text_color=\u00a0\u00bb#ffffff\u00a0\u00bb button_bg_color=\u00a0\u00bb#26c699&Prime; button_border_color=\u00a0\u00bbrgba(0,0,0,0)\u00a0\u00bb button_letter_spacing=\u00a0\u00bb1px\u00a0\u00bb button_font=\u00a0\u00bb|700||on|||||\u00a0\u00bb custom_padding=\u00a0\u00bb12px||12px||true|true\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1&Prime; fullwidth=\u00a0\u00bbon\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; 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global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; custom_padding=\u00a0\u00bb|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.16&Prime; text_font=\u00a0\u00bb||||||||\u00a0\u00bb text_line_height=\u00a0\u00bb2em\u00a0\u00bb ul_font=\u00a0\u00bb||||||||\u00a0\u00bb ol_font=\u00a0\u00bb||||||||\u00a0\u00bb header_font=\u00a0\u00bb||||||||\u00a0\u00bb header_2_font=\u00a0\u00bbFaustina|600|||||||\u00a0\u00bb header_2_font_size=\u00a0\u00bb42px\u00a0\u00bb header_2_line_height=\u00a0\u00bb1.4em\u00a0\u00bb header_3_font=\u00a0\u00bb||||||||\u00a0\u00bb header_4_font=\u00a0\u00bb||||||||\u00a0\u00bb header_5_font=\u00a0\u00bb||||||||\u00a0\u00bb header_6_font=\u00a0\u00bb||||||||\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb background_layout=\u00a0\u00bbdark\u00a0\u00bb max_width=\u00a0\u00bb600px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb header_2_font_size_tablet=\u00a0\u00bb32px\u00a0\u00bb header_2_font_size_phone=\u00a0\u00bb22px\u00a0\u00bb header_2_font_size_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n<h2>Prenez contact avec nous. Participez.<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.16&Prime; background_color=\u00a0\u00bb#ffffff\u00a0\u00bb max_width=\u00a0\u00bb850px\u00a0\u00bb custom_padding=\u00a0\u00bb60px|60px|60px|60px|true|true\u00a0\u00bb animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbtop\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb2%\u00a0\u00bb box_shadow_style=\u00a0\u00bbpreset3&Prime; box_shadow_vertical=\u00a0\u00bb40px\u00a0\u00bb box_shadow_blur=\u00a0\u00bb100px\u00a0\u00bb box_shadow_spread=\u00a0\u00bb-30px\u00a0\u00bb box_shadow_color=\u00a0\u00bbrgba(0,0,0,0.22)\u00a0\u00bb use_custom_width=\u00a0\u00bbon\u00a0\u00bb custom_width_px=\u00a0\u00bb850px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.16&Prime; custom_padding=\u00a0\u00bb|||\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_contact_form email=\u00a0\u00bbinfo@cureclcn4.org\u00a0\u00bb success_message=\u00a0\u00bbMerci de nous avoir contact\u00e9s. Nous vous contacterons bient\u00f4t.\u00a0\u00bb module_id=\u00a0\u00bbet_pb_contact_form_1&Prime; _builder_version=\u00a0\u00bb4.16&Prime; _unique_id=\u00a0\u00bbb592135d-fd4a-4acc-b88c-3ab937ffb6bd\u00a0\u00bb form_field_background_color=\u00a0\u00bbrgba(0,0,0,0)\u00a0\u00bb form_field_font=\u00a0\u00bb||||||||\u00a0\u00bb custom_button=\u00a0\u00bbon\u00a0\u00bb button_text_size=\u00a0\u00bb14px\u00a0\u00bb button_text_color=\u00a0\u00bb#ffffff\u00a0\u00bb button_bg_color=\u00a0\u00bb#26c699&Prime; button_border_width=\u00a0\u00bb8px\u00a0\u00bb button_border_color=\u00a0\u00bbrgba(0,0,0,0)\u00a0\u00bb button_letter_spacing=\u00a0\u00bb1px\u00a0\u00bb button_font=\u00a0\u00bb|700||on|||||\u00a0\u00bb border_radii=\u00a0\u00bbon|3px|3px|3px|3px\u00a0\u00bb border_width_all=\u00a0\u00bb1px\u00a0\u00bb border_color_all=\u00a0\u00bbrgba(51,51,51,0.15)\u00a0\u00bb form_background_color=\u00a0\u00bbrgba(0,0,0,0)\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_contact_field field_id=\u00a0\u00bbName\u00a0\u00bb field_title=\u00a0\u00bbNom\u00a0\u00bb _builder_version=\u00a0\u00bb4.16&Prime; 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Vous vous demandez ce que cela signifie ? Poursuivez votre lecture pour un r\u00e9sum\u00e9 facile \u00e0 comprendre !<\/p>\n","protected":false},"author":2,"featured_media":4013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[47],"tags":[],"class_list":["post-4103","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche"],"_links":{"self":[{"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/posts\/4103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/comments?post=4103"}],"version-history":[{"count":5,"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/posts\/4103\/revisions"}],"predecessor-version":[{"id":4108,"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/posts\/4103\/revisions\/4108"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/media\/4013"}],"wp:attachment":[{"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/media?parent=4103"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/categories?post=4103"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cureclcn4.org\/fr\/wp-json\/wp\/v2\/tags?post=4103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}